OMNICEF R PLM

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Dose adjustment in elderly patients is not necessary unless renal function is markedly compromised . The Cmax and AUC of cefdinir from the capsules are reduced by 16% and 10%, respectively, when given with a high-fat meal. In adults given the 250 mg/5 mL oral suspension with a high-fat meal, the Cmax and AUC of cefdinir are reduced by 44% and 33%, respectively.

OMNICEF is contraindicated in patients with known allergy to the cephalosporin class of antibiotics. Following administration of single 600-mg doses, cefdinir was not detected in human breast milk. As with other broad-spectrum antibiotics, prolonged treatment may result in the possible emergence and overgrowth of resistant organisms. If superinfection occurs during therapy, appropriate alternative therapy should be administered. There have been reports of reddish stools in patients receiving cefdinir. In many cases, patients were also receiving iron-containing products.

For the best effect, take this antibiotic at evenly spaced times. To help you remember, take this medication at the same time every day. Iron-fortified infant formula does not significantly interfere with the absorption of cefdinir.

300 mg PO every 12 hours or 600 mg PO every 24 hours for 5 to 7 days. The FDA-approved dosage is 300 mg PO every 12 hours for 5 to 10 days or 600 mg PO every 24 hours for 10 days. Oral extended-spectrum, semisynthetic, third generation cephalosporin. It is not active against methicillin-resistant staphylococci or Pseudomonas aeruginosa. Cefdinir is used for skin infections and a variety of upper respiratory infections.

Store the suspension at room temperature away from light and moisture. This medication may cause false positive results with certain diabetic urine testing products (cupric sulfate-type). This drug may also affect the results of certain lab tests. Make sure laboratory personnel and your doctors know you use this drug.

Like all beta-lactam antibiotics, the ability of cefdinir to interfere with PBP-mediated cell wall synthesis ultimately leads to cell lysis. Lysis is mediated by bacterial cell wall autolytic enzymes (i.e., autolysins). The relationship between PBPs and autolysins is unclear, but it is possible that the beta-lactam antibiotic interferes with an autolysin inhibitor. Bacterial resistance to cefdinir occurs as a result of hydrolysis by some beta-lactamases, alteration of the PBP, and decreased drug permeability. 300 mg PO every 12 hours or 600 mg PO every 24 hours for 10 days. Third-generation oral cephalosporins, such as cefdinir, are not recommended by the Infectious Disease Society of America for empiric monotherapy of acute bacterial sinusitis due to variable rates of S.

Cefdinir is a beta-lactam antibiotic like the penicillins and is mainly bactericidal. Cefdinir inhibits the third and final stage of bacterial cell wall synthesis by preferentially binding to specific penicillin-binding proteins that are located inside the bacterial cell wall. Penicillin-binding proteins are responsible for several steps in the synthesis of the cell wall and are found in quantities of several hundred to several thousand molecules per bacterial cell. Penicillin-binding proteins vary among different bacterial species. Thus, the intrinsic activity of cefdinir as well as the other cephalosporins and penicillins against a particular organism depends on their ability to gain access to and bind with the necessary PBP.

Guidelines do not recommend cefdinir for Group A Streptococcal pharyngitis to prevent rheumatic fever. Guidelines recommend cefdinir as an alternative to amoxicillin or amoxicillin; clavulanate for infections due to H. In rare cases, your doctor can prescribe Omnicef for other types of infections. Some patients can receive cefdinir for UTI , especially if the first- and second-course drugs didn't work.

The rate and extent of cefdinir absorption from the capsules are reduced by 16% and 10%, respectively, when given with a high-fat meal, however, the magnitude of these reductions is not likely to be clinically significant. Therefore, cefdinir may be taken without regard to meals. The recommended dosage and duration of treatment for infections in pediatric patients are described in the following chart; the total daily dose for all infections is 14 mg/kg, up to a maximum dose of 600 mg per day. Once-daily dosing for 10 days is as effective as BID dosing. Once-daily dosing has not been studied in skin infections; therefore, OMNICEF for Oral Suspension should be administered twice daily in this infection. OMNICEF for Oral Suspension may be administered without regard to meals.

Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. The effect of foods highly fortified with elemental iron (primarily iron-fortified breakfast cereals) on cefdinir absorption has not been studied. Pseudomembranous colitis symptoms may begin during or after antibiotic treatment . Caused by Staphylococcus aureus (including β-lactamase producing strains) and Streptococcus pyogenes. Omnicef is a cephalosporin antibiotic used to treat many different types of infections caused by bacteria.